Ultrasound to be used to destroy cancer tumours
I was very impressed with the news today that a person with rectal cancer in the UK had his tumour destroyed using Ultrasound.
In fact so impressed that i searched some past news and found this article from 2004.
You’ll be impressed. That piece of news was published in 16th Feb 2004 !
The treatment
An invisible knife that uses high-intensity sound waves to penetrate the body and destroy tumours is set to revolutionise cancer treatment, it is claimed.
In five to 10 years ultrasound could replace conventional surgery and radiotherapy for patients with many different types of cancer, scientists said.
About the technique
The technique is undergoing early trials for liver and kidney cancer in the UK while a French team using a different system has already achieved disease-free results treating men with prostate cancer.
In China, where the technology has been pioneered, anecdotal evidence from studies of thousands of patients is said to be “astounding”.
Ultrasound surgery focuses bursts of high energy sound waves on the tumour, heating it to a temperature of 60 degrees Celsius. The tumour cells are destroyed while surrounding tissue is left unharmed.
Professor Gail ter Haar, who is leading trials of an experimental system at the Royal Marsden Hospital in Sutton, Surrey, England, said the technique could treat tumours up to the size of a small orange.
Testing ultrasounds
At this stage the trials are confined to testing the safety of the technique, but Prof ter Haar said they had already yielded “really exciting results”.
She told the American Association for the Advancement of Science’s annual meeting in Seattle yesterday: “I think there will be cancers for which it will revolutionise treatment, but we’re a long way from knowing which they will be, and exactly how it should be employed”.
What is treatment?
Patients with liver and kidney cancer are taking part in the Royal Marsden studies.
Treatment consists of two-second long bursts of ultrasound delivered to the surface of the body by a machine mounted on a gantry.
A number of bursts are needed to clear an organ of cancer.
Testing accross the world
At a different centre in Oxford, England, Prof ter Haar has been using a commercial device developed in China to treat a similar group of patients.
She has worked with Chinese physicians who have already treated about 3,000 cancer patients with ultrasound.
Although the Chinese trials were not as scientifically rigorous as those in the UK, the anecdotal evidence was impressive.
“The results in China are really quite astounding,” said Prof ter Haar.
“There are patients who are disease free with tumours for which there are no other treatments, particularly in the pancreas.”
She said that theoretically, ultrasound should be suitable for a wide range of solid tumours.
“If you can image a tumour with diagnostic ultrasound you should be able to treat it,” she told the meeting.
Not all cancers can be targeted with ultrasound
However, since the sound beam could not travel through bone or air, certain cancers would be difficult to treat.
Brain tumours and lung cancers deep behind the rib cage fell into this category.
Thinking about the tough cancer areas
Scientists in the UK and United States were working on the problem of getting ultrasound into the brain.
“Its very appealing for the brain because it’s a trackless form of damage,” said Prof ter Haar.
“You only get damage at the focus so you don’t damage the rest of the brain through which you’ve got to travel. If we could solve that problem it would be very exciting.”
Different applications and challenges of ultrasound
Dr Jean-Yves Chapelon from the French research institute Inserm in Lyon described a different ultrasound system now at an advanced stage of development which he had used to treat 242 men with prostate cancer.
The results were due to be published in the next few months.
Dr Chapelon said the treatment was as effective as conventional surgery or radiotherapy, and safer.
In this case the ultrasound beam was delivered through the rectum. After five years of followup, 80 per cent of low-risk patients were found to be disease-free and effectively cured.
For medium-risk patients the success rate was 60 per cent and for patients with high-risk aggressive cancers, 50 per cent. The men had an average age of 71.
Traditional treatments for older men with prostate cancer carry a high risk of impotence and urinary incontinence, but 40 per cent of the patients recovered their potency and only eight per cent were unable to control their urine flow.
Impressive results
Not one patient had died of cancer although the first was treated as long as 11 years ago.
“We believe that this therapy challenges other therapies,” said Dr Chapelon.
However, he said that at present it was still difficult to convince specialists that ultrasound therapy could be as good as conventional treatment.
Prof ter Haar said there was still much work to do before ultrasound became universally available as a cancer treatment.
She expected the process of patient trials, publication of data, and introduction into hospitals to take between five and 10 years.
Other applications for ultrasound
Another possible application of ultrasound might be on the battlefield, according to Dr Shahram Vaezy, from the University of Washington in Seattle.
His team was working on miniaturising ultrasound equipment that could be used to treat wounded soldiers, or accident victims.
A big advantage of ultrasound was that it had the ability to stop bleeding by sealing broken blood vessels, he said.
Dr Vaezy told the meeting: “The application we are pursuing is treating internal bleeding, to develop a non-invasive method of treating patients at the scene of an accident, for example”.
Hypoglycaemia and Hyperglycaemia
If blood sugar levels fall or rise abnormally in someone with diabetes, they’ll experience a variety of symptoms.
Hypoglycaemia
Hypoglycaemia is when the blood sugar levels fall below normal. Glycaemia measures is the level of sugar in blood.
Hypoglycaemia may occur:
- after an insulin injection
- after taking oral diabetes medication
- if a meal is missed or delayed
- after strenuous exercise
- if alcohol is drunk on an empty stomach
The symptoms of hypoglycaemia vary from person to person. Mild hypoglycaemia may cause:
- weakness
- dizziness
- sweating
- hunger
- shaking
- irritability
- mood swings
A mild hypoglycaemia can usually be treated with some form of sugar. Types of sugar to use during mild crisis :
- dextrose tablets (carry these if you have diabetes)
- three sugar lumps
- two teaspoons of sugar
- chocolate or sweet biscuits
- a sweet drink
When the blood glucose level falls even lower, then the person may behave strangely and become confused (often mistakenly interpreted as drunkenness). Under these circumstances it may be easier and quicker to give sugar in liquid form, such as a sweet drink.
In severe hypoglycaemia, the person loses consciousness. Under these circumstances an injection of glucagon is given, which temporarily raises the level of blood glucose. Once the person is conscious they can be given some sugar and a snack to prevent the hypo from recurring.
Always have sugar tablets or another form of sugar available
People with diabetes and those close to them are taught to look out for signs that their sugar level may be low, and are advised to always have sugar tablets or another form of sugar available to raise the level quickly. This solves the problem quickly and prevents serious consequences.
People with diabetes are advised to carry some form of identification saying that they have diabetes, so that people will realise their condition should they get into difficulty and need help.
Hyperglycaemia
Hyperglycaemia is when the blood glucose level is too high. When it’s mildly raised then symptoms of uncontrolled diabetes occur, namely excessive thirst, passing urine frequently, tiredness, weakness and lethargy.
If the blood glucose level becomes dangerously high then the person becomes dehydrated and may become comatose. This is a medical emergency that requires hospital treatment.
Mom: Son in coma heard everything for 23 years
There was this piece of news yesterday from AFP that was so incredible that i reproduce it here.
A man who emerged from what doctors thought was a vegetative state says he was fully conscious for 23 years but could not respond because he was paralyzed, his mother said Monday.
Rom Houben, 46, had a car crash in 1983 and doctors thought he had sunk into a coma. His family continued to believe their son was conscious and sought further medical advice.
Professor Steven Laureys of Belgium’s Coma Science Group realized that the diagnosis was wrong and taught Houben how to communicate through a special keyboard, said Dr. Audrey Vanhaudenhuyse, who is on Laureys’ team.
Rom used the device to tell a reporter for the German magazine Der Spiegel that: “I screamed but there was nothing to hear.”
Belgian doctors who treated him early on said that Rom had gone from a coma into a vegetative condition.
Coma is a state of unconsciousness in which the eyes are closed and the patient can’t be roused, as if simply asleep. A vegetative state is a condition in which the eyes are open and can move, and the patient has periods of sleep and periods of wakefulness, but remains unconscious and unaware of him or herself or others. The patient can’t think, reason, respond, do anything on purpose, chew or swallow.
But Rom’s parents would not accept that he was comatose or vegetative.
His mother, Fina Houben, said in a telephone interview that they took him five times to the United States for tests.
More searching finally got her in touch with Laureys, who put Houben through a PET scan that indicated he was conscious. The family and doctors then began trying to establish communication.
A breakthrough came when he was able to indicate yes or no by slightly moving his foot to push a computer device placed there by Laureys’ team.
Then came the spelling of words using his finger and a touch-screen attached to his wheelchair.
“You have to imagine yourself lying in bed wanting to speak and move but unable to do so — while in your head you are OK,” Vanhaudenhuyse said. “It was extremely difficult for him and he showed a lot of anger, which is normal since he was very frustrated,” she said.
The case came to light after Laureys published a study in the journal BMC Neurology this year showing that about four out of ten patients with consciousness disorders are wrongly diagnosed as being a vegetative state. Houben, although not specifically mentioned, was part of the study.
Houben has started writing a book on his experiences.
Eating disorders in men and women
Eating disorders among men are on the rise, with recent NHS findings showing that as many as a quarter of people who suffer from eating disorders are male.
The NHS Information Centre (NHS IC) research – The Adult Psychiatric Morbidity Survey 2007 – published last month, surveyed 7,461 people in England over 16. It found that an alarming 6.4 per cent of adults had a problem with food, a figure much higher than previously thought.
Females are ten times more likely than males to suffer from anorexia or bulimia, according to the Royal College of Psychiatrists. However, the NHS research suggests that eating disorders are becoming more common in boys and men.
Eating disorders in men can take different forms to those in women, as they “tend to be more focused on body image,” Mary George from eating disorder charity Beat, said. She explained that “visits to the gym become obsessive as does the desire to change body shape – this then becomes accompanied by controlling calorie intake which leads to a full blown eating disorder.”
Common disorders
The most common forms of eating disorder are anorexia nervosa, where individuals starve themselves and excessively exercise to lose weight, and bulimia, in which they binge on food and then purge through vomiting or laxative use. Anorexia accounts for around one in ten cases in adults, according to figures from the National Institute for Health and Clinical Excellence (NICE), whereas bulimia accounts for a third of all cases, with other disorders such as compulsive eating making up the rest.
The disorders can range in severity and can be a major cause of serious psychological distress. The physical impact of a disorder such as anorexia can be devastating, resulting in drastic weight loss, low mood, a loss of periods in women, and in more acute cases, heart problems and osteoporosis.
In its eating disorder guidelines, NICE states that some studies have identified eating disorders as having the highest mortality rate of all mental disorders, illustrating the potential severity of these disorders.
A taboo subject
“Many men don’t realise that they have an eating disorder and are reluctant to seek help when they do feel they have a problem,” commented Beat’s Mary George on why eating disorders are usually associated with women.
The silence surrounding male anorexia and bulimia has meant the issue has become something of a taboo subject, but it was cast under the spotlight last year when former deputy prime minister, John Prescott, admitted that he had suffered from bulimia in the past.
Following Mr Prescott’s revelation, Ms George said the charity’s helplines “had ten times the normal number of calls for men who hadn’t realised they had an eating disorder until then.”
The authors of the NHS survey concluded that although research into male eating disorders was expanding, “men with eating disorders are a group that have been neglected in research, policy and clinical practice in this area”.
A complex issue – for both sexes
Problems with food can begin when it is used to cope with those times when someone is bored, anxious, angry, lonely, ashamed or sad, or when it is used as a crutch to help relieve painful situations, says Beat.
The recent tragic death of 18 year-old Alice Rae refocuses from beyond the statistics the very real and human cost of anorexia. Alice died in January of this year; found dead in bed by her mother at the family home in Houghton, Hampshire, after battling with anorexia.
The fashion industry has come under recent scrutiny for its promotion of ’size zero’ models and the message this gives out to young women about body image. But specialists, such as the National Centre for Eating Disorders, suggest reasons why someone should develop an eating disorder are complex, and each case is individual. Factors such as low self-esteem, family relationships, problems with friends, dealing with grief, problems at work or university, or sexual or emotional abuse can all play a part.
Help at hand?
Eating disorders are serious mental health issues and can be very distressing for both those with the disorder and their families, as studies show.
According to a report published by Beat in February 2008 entitled Failing Families?, 79 per cent of families surveyed said that an eating disorder had caused lasting damage to their lives. Relationship breakdown; problems at work caused by the need to take time off to provide care and support; damage to friendships and social life and a negative impact on other children in the family were all listed as factors.
Despite NICE guidance advising that “families and carers should be informed of self help and support groups and offered the opportunity to participate in such groups”, Beat’s survey found that only 12 per cent of families felt they had access to the amount of support they needed and 23 per cent had no support at all.
The NHS survey reinforces this need for improved support and treatment of those with eating disorders, finding that four in five adults (81 per cent) who screened positive for an eating disorder were not receiving any counseling, medication or therapy for a mental or emotional problem.
In response to the NHS report findings, Conservative health spokesperson Anne Milton said: “These figures are shocking. We are failing to get across to young people today the dangers they face when they abuse food. At one end of the scale we have some frightening statistics on obesity and on the other end of the scale we have many people suffering from this tragic illness.”
